王翀


王 翀 助理教授/硕导

学科(方向):病理学

所在系部:基础医学部

办公电话:0592-2185735

邮    箱:wangchong@xmu.edu.cn


研究领域:

主要致力于信号转导和基因调控研究,阐明帕金森病和肝癌等重大疾病发生发展的分子机制,为疾病诊治提供科学依据。首次发现Egr-1转录调控BimCaMKII磷酸化GSK-3等信号通路,阐明了SOX7在肝癌发生及神经元凋亡中的作用。

学习经历:

2001~2006 中山大学中山医正规赌博十大网站app法医学专业 医学学士;

2006~2011 中山大学中山医正规赌博十大网站app药理学专业 医学博士。

工作经历:

2012~2018 正规赌博十大网站app 助理教授

代表性成果:

  1. Yiwei Zhao#, Lin Zhu#, Shaojun Yu, Jing Zhu, Chong Wang*. CaMKII inhibition promotes neuronal apoptosis by transcriptionally upregulating Bim expression, Neuroreport, 2016, 27(14):1018-1023.

  2. Chong Wang#*, Lina Qin#, Zhiqun Min, Yiwei Zhao, Lin Zhu, Jin Zhu, Shaojun Yu. SOX7 interferes with beta-catenin activity to promote neuronal apoptosis, The European journal of neuroscience, 2015, 41(11):1430-1437.

  3. Chong Wang#*, Yu Guo, Jing Wang, Zhiqun Min. Annexin A2 knockdown inhibits hepatoma cell growth and sensitizes hepatoma cells to 5-fluorouracil by regulating beta-catenin and cyclin D1 expression, Molecular medicine reports, 2015, 11(3):2147-2152.

  4. Chong Wang#*, Yu Guo#, Jing Wang, Zhiqun Min. The suppressive role of SOX7 in hepatocarcinogenesis, PloS one, 2014, 9(5):e97433.

  5. Bo Xie#, Chong Wang#, Zhihao Zheng#, Bin Song, Chi Ma, Gerald Thiel, Mingtao Li*. Egr-1 transactivates Bim gene expression to promote neuronal apoptosis, The Journal of neuroscience, 2011, 31(13):5032-5044.

主持过的重要课题:

  1. 国家自然科学基金,SOX7抑制肝癌发生的机制研究,2016.01-2018.12

  2. 福建省自然科学基金,神经元凋亡时Bim的调控新机制研究,2014.01-2016.12

  3. 中央高校基本业务费,新型分子病理诊断技术的开发,2013.01-2014.12

所有论文列表:

  1. Yiwei Zhao#, Lin Zhu#, Shaojun Yu, Jing Zhu, Chong Wang*. CaMKII inhibition promotes neuronal apoptosis by transcriptionally upregulating Bim expression, Neuroreport, 2016, 27(14):1018-1023.

  2. Chong Wang#*, Lina Qin#, Zhiqun Min, Yiwei Zhao, Lin Zhu, Jin Zhu, Shaojun Yu. SOX7 interferes with beta-catenin activity to promote neuronal apoptosis, The European journal of neuroscience, 2015, 41(11):1430-1437.

  3. Chong Wang#*, Yu Guo, Jing Wang, Zhiqun Min. Annexin A2 knockdown inhibits hepatoma cell growth and sensitizes hepatoma cells to 5-fluorouracil by regulating beta-catenin and cyclin D1 expression, Molecular medicine reports, 2015, 11(3):2147-2152.

  4. Chong Wang#*, Yu Guo#, Jing Wang, Zhiqun Min. The suppressive role of SOX7 in hepatocarcinogenesis, PloS one, 2014, 9(5):e97433.

  5. Bin Song#, Bo Xie#, Chong Wang, Mingtao Li*. c-Jun induction is independent of early growth response factor during cerebellar granule neuron apoptosis, Neuroreport, 2012, 23(2):67-72.

  6. Bo Xie#, Chong Wang#, Zhihao Zheng#, Bin Song, Chi Ma, Gerald Thiel, Mingtao Li*. Egr-1 transactivates Bim gene expression to promote neuronal apoptosis, The Journal of neuroscience, 2011, 31(13):5032-5044.

  7. Bin Song#, Bo Xie#, Chong Wang, Mingtao Li*. Caspase-3 is a target gene of c-Jun:ATF2 heterodimers during apoptosis induced by activity deprivation in cerebellar granule neurons, Neuroscience letters, 2011, 505(2):76-81.

  8. Bin Song#, Bingquan Lai#, Zhihao Zheng#, Yuying Zhang, Jingyan Luo, Chong Wang, Yuan Chen, James R. Woodgett, Mingtao Li*. Inhibitory phosphorylation of GSK-3 by CaMKII couples depolarization to neuronal survival, The Journal of biological chemistry, 2010, 285(52):41122-41134.

  9. Wei Liu#, Xingwang Zhou#, Shaojun Liu, Kunhua Hu, Chong Wang, Qingyu He, Mingtao Li*. Calpain-truncated CRMP-3 and -4 contribute to potassium deprivation-induced apoptosis of cerebellar granule neurons, Proteomics, 2009, 9(14):3712-3728.


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