鲁金花

鲁金花, 博士

职称:助理教授 

学科(专业):生殖医学

研究方向:胚胎植入和胎盘发育

电子邮箱:jhlu@xmu.edu.cn 

电话:0592-2880503


教育背景

2008.9-2013.7中国科正规赌博十大网站app动物研究所发育生物学专业 博士

2005.9-2008.7山东农业大学动物遗传育种和繁殖专业 硕士

2001.9-2005.7山东农业大学动物科学专业 本科      


工作经历

2015.12-至今   正规赌博十大网站app基础医学系生殖医学 助理教授

2013.7-2015.12中国科正规赌博十大网站app动物研究所胚胎着床生理学研究组 博士后


主要研究领域:

主要研究领域是胎盘发育的调控机制研究,以转基因和组织特异性敲除小鼠模型以及滋养层干细胞细胞系为研究手段,结合临床病例研究胎盘发育过程中滋养层细胞增殖和谱系分化的调控机制,为妊娠相关疾病的预防和治疗提供依据。


主要学术成果:

论文:

1、Jiang YF, Kong SB, He B, Wang BY, Wang HB*, Lu JH* (Co-correspondence). Uterine Prx2 restrains decidual differentiation through inhibiting lipolysis in mice. Cell Tiss Res. 365(2): 403-14, 2016

2、Lu JH, Zhang S, Nakano H, Wang SM, Simmons DG, Shuang BK, Wang   Q, Shen LJ, Tu ZW, Wang WX, Wang BY, Wang HM, Wang YL, van Es JH, Clevers H, Leone G, Cross JC*, Wang HB*(*Co-correspondence). A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biol. 11(4): e1001536, 2013

3、Lu JH*, Wang Q*(*equal contribution), Wang BY, Wang FC, Wang HB. Developmental genes during placentation: insights from mouse mutants. Front Biol. 6(4): 300–311, 2011

4、Lu JH, Wang JZ, Wang HL, Sui HS, Liu Y, Li JJ, Liang B, Tan JH. Damaging effect of cumulus denudation on rabbit oocytes. Fertil Steril. 93(5):1567-73, 2010

5、Wang Q, Lu JH, Zhang S, Wang SM, Wang WX,, Wang BY, Wang FC, Chen Q, Duan EK, Kispert A, Wang HB. Wnt6 is essential for stromal cell proliferation during decidualization. Biol Reprod. 88(1): 5, 2013

6、Liu Y, Wang HL, Lu JH, Miao YL, Cao XY, Zhang L, Wu X, Wu F, Ding B, Wang R, Luo M, Li W, Tan JH. Rex Rabbit Somatic Cell Nuclear Transfer with In Vitro-Matured Oocytes. Cell Reprogram. 18(3): 187-94, 2016 

7、Chen Q*, Zhang Y*( equal contribution), Lu JH, Wang Q, Wang SJ, Cao YJ, Wang HB*, Duan EK*(*Co-correspondence). Embryo-uterine cross-talk during implantation: The role of Wnt signaling. Mol Hum Reprod. 15(4): 215-21, 2009

8、Zhang S, Kong SB, Lu JH, Wang Q, Chen YJ, Wang WW, Wang BY, Wang HB. Deciphering the molecular basis of uterine receptivity. Mol Reprod Dev. 80(1): 8-21, 2013

9、Lu WG, Tu ZW, Wang SM, Lu JH, Wang Q, Wang WX, Wang BY, Wang HB, Ni HM, Guo Yong. Spatiotemporal expression of Wnt signaling pathway components during bovine placental development. Theriogenology. 80(8): 893-902, 2013

10、Tu ZW, Wang Q, Cui TT, Wang JR, Ran H, Bao HL, Lu JH, Wang BY, Lydon JP, DeMayo F, Zhang S, Kong SB*, Wu XM*, Wang HB*. Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice. Cell Death Differ. 23(1): 169-81, 2016

11、Zhang S, Kong SB, Wang BY, Cheng XH, Chen YJ, Wu WW, Wang Q, Shi JC, Zhang Y, Wang SM, Lu JH, Lydon JP, DeMayo F, Pear WS, Han H, lin HY, Li L, Wang HM, Wang YL, Li B, Chen Q, Duan EK, Wang HB (Co-correspondence). Uterine Rbpj is required for embryo-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms. Cell Res .doi:10.1038/cr.2014.82, 2014

12、Fu Z*, Wang BY*, Wang SM*, Wu WW*(*equal contribution), Wang Q, Chen YJ, Kong SB, Lu JH, Tang ZZ, Ran H, Tu ZW, He B, Zhang S, Chen Q, Jin WZ, Duan EK, Wang HM, Wang YL, Li L, Wang FC*, Gao SR* , W HB*(*Co-correspondence). Integral proteomic analysis of blastocysts reveals key molecular machinery governing embryonic diapause and reactivation for implantation in mice. Biol Reprod. 90(3): 52, 2014

13、Wang HL, Sui HS, Liu Y, Miao DQ, Lu JH, Liang B, Tan JH. Dynamic changes of germinal vesicle chromatin configuration and transcriptional activity during maturation of rabbit follicles. Fertil Steril. 91(4 Suppl):1589-94, 2009

14、Yu JN, Ma SF, Miao DQ, Tan XW, Liu XY, Lu JH, Tan JH. Effects of cell cycle status on the efficiency of liposome-mediated gene transfection in mouse fetal fibroblasts. J Reprod Dev. 52(3): 373-82, 2006

主持课题:

1、中国博士后科学基金第55批面上资助,Polycomb 蛋白Bmi-1对小鼠胚泡植入和子宫蜕膜化的调控,2014.5-2015.6

获奖:

1、2015妇幼健康科学技术奖自然科学奖一等奖, 早期妊娠的分子调控(3/12)

2、2013中国科正规赌博十大网站app朱李月华优秀博士生奖

3、2013中国科正规赌博十大网站app三好学生及三好学生标兵

4、2013中国科正规赌博十大网站app动物研究所计划生育生殖生物学国家重点实验室优秀学生

5、2012 The 2nd SKLRB Symposium on Frontiers in Reproductive Biology Award for Excellent Poster Presentation 

6、2012 The State Key Laboratory of Reproductive Biology Young Scholars Forum Award for Brilliant Speech

7、2003国家奖学金




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