李娟

李 娟 助理教授

学科(方向):感染免疫

所在系部:基础医学部

办公电话:0592-2188675

箱:muzinvkouyue1983163.com


研究领域:

主要研究领域:1.幽门螺杆菌及其相关疾病,包括H. pylori的基因诊断、分子分型;H. pylori与胃粘膜上皮细胞间质转化及胃癌发生;幽门螺杆菌降解产物对细菌感染及免疫反应的抑制等。2.神经免疫调控:包括介质对免疫细胞表面神经递质受体的调控作用及对免疫反应发生的影响和作用机制;介质对神经细胞表面相应受体的调控作用及对神经细胞增殖凋亡的影响和相关作用机制。

学习经历:

2000~2005  山西医科大学临床医学专业 医学学士;

2005~2010  中山大学医正规赌博十大网站app基础医学专业   医学博士;


工作经历:

2010~2013 广州医科大学第二附属医院  讲师;

2013~至今 正规赌博十大网站app  助理教授;

代表性成果

1. Juan Li, Zhiying Ou, Fangjin Wang, Yu Guo, Ren Zhang, Jun Zhang, Peiqiong Li, Weijie Xu, Yunshao He. Distinctiveness of the cagA Genotype in Children and Adults with Peptic Symptoms in South China. Helicobacter 2009,14:248 -255. DOI: 10.1111/j.1523-5378.2009.00690.x PMID: 19674128


2. Juan Li, Fangjin Wang, Qiang Zhou, Zhiying Ou, Hongyun Jia, Xiaoyan Deng, Yunshao He, Xiaoman Wu. IL-1 polymorphisms in children with peptic symptoms in South China.Helicobacter 2011,Jun;16 (3):246-251.DOI:10.1111/j.1523-5378.2011.00837.xPMID: 21585612

3. Yan, Hong Qiong;   Huang, Xiao Bo;   Ke, Shi Zhong;   Jiang, Yi Na;   Zhang, Yue Hua;   Wang, Yi Nan;   Li, Juan;   Gao, Feng Guang. Interleukin 6 augments lung cancer chemotherapeutic resistance via ataxia-telangiectasia mutated/NF-kappaB pathway activation, Cancer Science, 2014105(9), 1220-1227.DOI: 10.1111/cas.12478PMID: 24988892 PMCID: PMC4462389

4. Wang Fang, Wang Yan Yan, Li Juan, You Xiang, Qiu, Xin Hui, Wang, Yi Nan,   Gao Feng Guang. Increased Antigen Presentation but Impaired T Cells Priming after Upregulation of Interferon-Beta Induced by Lipopolysaccharides Is Mediated by Upregulation of B7H1 and GITRL PLos One, 2014, 9(8). DOI:10.1371/journal.pone.0105636 PMID: 25144375 PMCID: PMC4140801

 5. Yanyan Wang, Chunfang Hu, Juan Li, Xiang You, Fengguang Gao. Increased translocation of antigens to endosomes and TLR4 mediated endosomal recruitment of TAP contribute to nicotine augmented cross-presentation, Oncotarget, 2016,Jun;21;7(25):38451-38466.DOI:10.18632/oncotarget.9498 PMID:27224911 PMCID:PMC5122403

 6. Jun Zhang, Pei-qiong Li, Qi-hong Yu, Hua-yun Chen, Juan Li, Yun-shao He. Development of a Multiplex Quantitative Fluorescent PCR Assay for Identification of Rearrangements in the AZFb and AZFc Region. Molecular Human Reproduction 2008, 14:371-6. DOI:10.1093/molehr/gan022 PMID: 18445645

7. Pei-qiong Li, Jun Zhang, Claude P. Muller, Jing-xian Chen, Zi-feng Yang, Ren Zhang, Juan Li, Yun-shao He. Development of a multiplex real-time polymerase chain reaction for the detection of influenza virus type A including H5 and H9 subtypes. Diagnostic Microbiology and Infectious Disease 2008, 61:192–197. DOI:10.1016/j.diagmicrobio.2008.01.007 PMID: 18296004

主持过的重要课题

  1. 福建省教育厅JA15014  HP(2-20)通过NOX2降低巨噬细胞消化能力的研究;

  2. 福建省科技厅2017J05140幽门螺杆菌促进胃粘膜上皮间质转化的研究。


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