?洪晓婷

洪晓婷 助理教授/硕导

学科(方向):病理生理学/肿瘤转移

所在系部: 基础医学部

办公电话:0592-2188421

邮    箱:xthong@xmu.edu.cn


研究领域:

肿瘤侵袭转移是肿瘤预后差的主要原因。侵袭转移的特性与肿瘤细胞和正常细胞间相互作用密切相关。我们主要从细胞间通讯方式着手,从细胞间缝隙连接,旁分泌,外泌体等多种途径分析肠癌,胶质瘤及乳腺癌及等多种肿瘤生长的微环境对肿瘤侵袭转移的影响。

学习经历:

2002~2007 中山大学中山医正规赌博十大网站app临床医学系 学士;

2007~2012 中山大学中山医正规赌博十大网站app药理学 博士;

2010~2012 美国罗格斯大学新泽西医正规赌博十大网站app药理生理学系 访问博士生。


工作经历:

2013~2015  加拿大英属哥伦比亚大学细胞生理科学系  博士后;

2015 ~今   正规赌博十大网站app  助理教授。



代表性成果:

1. Hong X, Sin WC, Harris AL and Naus CC. Gap junctions modulate glioma invasion by direct transfer of microRNA. Oncotarget. 2015; 6(17):15566-15577.

2.Hong X, Wang Q, Yang Y, Zheng S, Tong X, Zhang S, Tao L and Harris AL. Gap junctions propagate opposite effects in normal and tumor testicular cells in response to cisplatin. Cancer letters. 2012; 317(2):165-171.

主持过的重要课题:

1. Mir-5096通过激活星形胶质细胞促进胶质瘤侵袭的机制研究;国家自然科学基金青年基金项目;2017-2019,在研,项目负责人

2. Meninp53相互调控网络影响肝癌发生发展的分子机制研究;福建省自然科学基金面上项目; 2016-2019,在研,项目负责人


所有论文列表:

1.  Hong X, Sin WC, Harris AL and Naus CC. Gap junctions modulate glioma invasion by direct transfer of microRNA. Oncotarget. 2015; 6(17):15566-15577.

2.  Hong X, Wang Q, Yang Y, Zheng S, Tong X, Zhang S, Tao L and Harris AL. Gap junctions propagate opposite effects in normal and tumor testicular cells in response to cisplatin. Cancer letters. 2012; 317(2):165-171.

3.  Suzhi Z, Liang T, Yuexia P, Lucy L, Xiaoting H, Yuan Z and Qin W. Gap Junctions Enhance the Antiproliferative Effect of MicroRNA-124-3p in Glioblastoma Cells. Journal of cellular physiology. 2015; 230(10):2476-2488.

4.  Gielen PR, Aftab Q, Ma N, Chen VC, Hong X, Lozinsky S, Naus CC and Sin WC. Connexin43 confers Temozolomide resistance in human glioma cells by modulating the mitochondrial apoptosis pathway. Neuropharmacology. 2013; 75:539-548.

5.  Wang Q, You T, Yuan D, Han X, Hong X, He B, Wang L, Tong X, Tao L and Harris AL. Cisplatin and oxaliplatin inhibit gap junctional communication by direct action and by reduction of connexin expression, thereby counteracting cytotoxic efficacy. The Journal of pharmacology and experimental therapeutics. 2010; 333(3):903-911.

6.  He B, Tong X, Wang L, Wang Q, Ye H, Liu B, Hong X, Tao L and Harris AL. Tramadol and flurbiprofen depress the cytotoxicity of cisplatin via their effects on gap junctions. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009; 15(18):5803-5810.


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