宋刚

宋刚 福建省新世纪优秀人才、

厦门市重点引进人才


职称:教授/博导

学科(专业):肿瘤学

研究方向:细胞分子生物学

邮箱:gangsongsd@xmu.edu.cn

电话:0592-2188275


教育背景:

1994-1998 烟台师范正规赌博十大网站app 生物学系 本科

1998-2001 福建农林大学  生物技术 硕士

2003-2006 厦门大学 细胞生物学 博士


工作经历:

2006-2008 香港中文大学癌症中心 Research Associate

2008.7-至今 正规赌博十大网站app  教师


主要研究领域:

肿瘤发生发展过程中的信号转导。目前涉及:1)USPs调控p53等通路;2)MSCs调控肿瘤的转移;3)抗肿瘤的天然药物的筛选与作用机理。

主要学术成果:

论文:

1

Wang WW, Zhong W, Yuan JH, Tong YP, Yan CC, Hu SP, Mao YB, Zhang B, Hu TH, Song G*. Involvement   of wnt/β-catenin Signaling in the mesenchymal stem cellspromote   metastatic growth and chemoresistance ofcholangiocarcinoma.Oncotarget.   2015; 6(39): 42276-89.

2

Zhou H, Xu MY, Gao Y,   Deng ZG, Cao HW, Zhang WQ, Wang Q, Zhang B, Song G*, Zhan YY*, Hu TH*. Matrine Induces Caspase-Independent Program   Cell Death in Hepatocellular Carcinoma through Bid-Mediated Nuclear   Translocation of Apoptosis Inducing Factor. Mol Cancer. 2014, 13(59)1-11.

3

Zhang JF,   Cao HL, Zhang B, Cao HW, Xu XQ, Ruan H, Yi TT, Tan L, Qu R, Song G*, Wang BM*, Hu TH*. Berberine Potently   Attenuates Intestinal Polyps Growth in ApcMin mice and Familial Adenomatous   Polyposis Patients through Inhibition of Wnt Signaling.J Cell Mol Med. 2013. 17(11):1484-93.

4

Hu   C#, Song G#,*, ZhangB, Liu Z, Chen R, Hu TH*.Intestinal metabolite   compound K of panaxoside inhibits the growth of gastric carcinoma by   augmenting apoptosis via Bid-mediated mitochondrial pathway.J Cell   Mol Med.2012, 16(1):96-106.

5

Song G*, Guo S, Wang W, Hu C, Mao Y, Zhang B, Hu T*. Intestinal metabolite compound K of ginseng saponin potently   attenuating metastatic growth of hepatocellular carcinoma by augmenting   apoptosis via Bid-mediated mitochondrial pathway. J Agric Food Chem. 2010, 58(24):12753-60.

6

Song G, Chen GG, Hu   TH and Lai PBS. Bid Stands at the Crossroad of Stress-response Pathways. Current   Cancer Drug Targets.2010. 10 (6): 584-92.

7

Song G,Ouyang G, Mao YB, Ming YL, Bao S, Hu TH. Osteopontin   promotes metastatic growth of gastric cancer by augmenting cell survival and   invasion through Akt-mediated HIF-1α up-regulation and MMP9 activation.   J Cell Mol Med. 2009, 13(8B):1706-18.

8

Song G,   Chen GG, Yun JP and Lai PBS. Association of p53 with Bid induces cell   death in response to etoposide treatment in hepatocellular carcinoma.   Current Cancer Drug Targets. 2009,   9(7): 871-80.

9

Song G, Cai QF, Mao YB, Ming YL, Bao S, Ouyang G.. Osteopontin promotes ovarian cancer   progression and cell survival and increases HIF-1α expression through the   PI3-K/Akt pathway.Cancer   Sci. 2008, 10: 1901-7.

10

Song G, Chen GG, Chau DK, Miao J, Lai PBS. Bid exhibits S phase checkpoint activation   and plays a pro-apoptotic role in response to etoposide-induced DNA damage in   hepatocellular carcinoma cells. Apoptosis. 2008, 13(5):   693-701.

主持课题:

1

国家自然科学基金,胞外基质蛋白类在MSCs调控肠炎及其恶变过程中的功能研究, 2015.01-2018.12

2

国家自然科学基金, MSCs靶向ATM/BID/NOD1/2通路对肠炎及其恶化的调控机制,2013.01-2016.12

3

厦门市科技计划项目,抗肠炎及其恶性转化的人参皂甙次级代谢产物的筛选,2014.01-2016.12

4

福建省重点项目,泛素特异性蛋白酶USP39对肿瘤细胞炎性微环境的调控,2017.04-2019.03



获奖:

1

厦门市科技进步二等奖,传统中药治疗消化道恶性肿瘤的作用机制与临床应用,2015.12


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