吴亚林


吴亚林 教授/博导

学科(方向):眼科学

所在系部:眼视光系

办公电话:0592-2183761

箱:yalinw@xmu.edu.cn

系部网址:https://eye.xmu.edu.cn/index.jsp


研究领域

    年龄相关性黄斑变性(AMD)是全球成人和我国中老年人群重度视力丧失甚至不可逆性的首要原因,俨然已经成为严重的公共卫生问题,极大地影响了我国中老年人的身体健康和生活质量,给国家和个人带来了沉重的思想及经济负担,严重地制约着我国的经济发展。常染色体隐性Stargardt病(STGD1也称为少年性黄斑变性,是一种原发于视网膜色素上皮层的遗传性眼病,同样也使得数以万计的患者遭受失明的痛苦。本课题组主要从事AMDSTGD1发病机制及靶向防治药物开发的研究。

学习经历

1998~2002 南京工业大学制药与生命科学正规赌博十大网站app 生物化工专业 工学学士

2002~2007浙江大学化学系 化学生物学专业 理学博士

工作经历

2007~2011  美国哥伦比亚大学 化学系/眼科系 博士后

2011~2015  浙江大学药正规赌博十大网站app 药理毒理研究所 特聘研究员、博导

2012~2015 浙江大学医正规赌博十大网站app附属第二医院眼科中心 特聘教授(兼)

2015~至今 正规赌博十大网站app眼科研究所 教授、博导

代表性成果(*通讯作者)

  1. Liao Y#, Zhang H#, He D, Wang Y, Cai B, Chen J, Ma J, Liu Z, and Wu Y*. Retinal pigment epithelium cell death is associated with NLRP3 inflammasome activation by all-trans retinal. Invest. Ophthalmol. Vis. Sci. 2019, 60(8), 3034-3045.

  2. Gao Z, Liao Y, Chen C, Liao C, He D, Chen J, Ma J, Liu Z, and Wu Y*. Conversion of all-trans-retinal into all-trans-retinal dimer reflects an alternative metabolic/antidotal pathway of all-trans-retinal in the retina. J. Biol. Chem. 2018, 293(37), 14507-14519.                                         

  3. Zhao J, Liao Y, Chen J, Dong X, Gao Z, Zhang H, Wu X, Liu Z, and Wu Y*. Aberrant buildup of all-trans-retinal dimer, a non-pyridinium bisretinoid lipofuscin fluorophore, contributes to the degeneration of the retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci. 2017, 58(2), 1063-1075.

  4. Li J, Zhang Y, Cai X, Xia Q, Chen J, Liao Y, Liu Z, and Wu Y*. All-trans-retinal dimer formation alleviates the cytotoxicity of all-trans-retinal in human retinal pigment epithelial cells. Toxicology 2016, 371, 41-48.

  5. Liu X, Chen J, Liu Z, Li J, Yao K*, and Wu Y*. Potential therapeutic agents against retinal diseases caused by aberrant metabolism of retinoids. Invest. Ophthalmol. Vis. Sci. 2016, 57(3), 1017-1030.

  6. Zhang J#, Bai Y#, Qi Y, Zhang Q, Li S, Huang L, Wu Y*, and Li X*. Protective effect of autophagy on human retinal pigment epithelial cells against lipofuscin fluorophore A2E: implications for age-related macular degeneration. Cell Death Dis. 2015, 6, e1972.

  7. Li J, Cai X, Xia Q, Yao K, Chen J, Zhang Y, Naranmandura H, Liu X, and Wu Y*. Involvement of endoplasmic reticulum stress in all-trans-retinal induced retinal pigment epithelium degeneration. Toxicol. Sci. 2015, 143(1), 196-208.

  8. Zhao J, Yao K, Jin Q, Jiang K, Chen J, Liu Z, Li J, and Wu Y*. Preparative and biosynthetic insights into pdA2E and isopdA2E, retinal-derived fluorophores of retinal pigment epithelial lipofuscin. Invest. Ophthalmol. Vis. Sci. 2014, 55(12), 8241-8250.

  9. Wu Y*, Jin Q, Yao K, Zhao J, Chen J, Wu X, Gan L, Li J, Song X, Liu X, and Cai X. Retinal metabolism in humans induces the formation of an unprecedented lipofuscin fluorophore 'pdA2E'. Biochem. J. 2014, 460(3), 343-352.

  10. Li J, Yao K, Yu X, Dong X, Gan L, Luo C, and Wu Y*. Identification of a novel lipofuscin pigment (iisoA2E) in retina and its effects in the retinal pigment epithelial cells. J. Biol. Chem. 2013, 288(50), 35671-35682.

  11. Wu Y, Zhou J, Fishkin NE, Rittman BE, and Sparrow JR. Enzymatic degradation of A2E, a retinal pigment epithelial lipofuscin bisretinoid. J. Am. Chem. Soc. 2011, 133(4), 849-857.

  12. Wu Y, Yanase E, Feng X, Siegel M, and Sparrow JR. Structural characterization of bisretinoid A2E photocleavage products and implications for age-related macular degeneration. Proc. Natl. Acad. Sci. U.S.A. 2010, 107(16), 7275-7280.

  13. Wu Y, Fishkin NE, Pande A, Pande J, and Sparrow JR. Novel lipofuscin bisretinoids prominent in human retina and in a model of recessive Stargardt disease. J. Biol. Chem. 2009, 284(30), 20155-20166.


主持过的重要课题

  1. 国家自然科学基金面上项目,2019/01-2022/1257万,主持

  2. 国家自然科学基金面上项目,2016/01-2019/1257万,主持

  3. 国家自然科学基金面上项目,2013/01-2016/1270万,主持

  4. 国家自然科学基金青年项目,2013/01-2015/1225万,主持

  5. 福建省自然科学基金面上项目,2017/04-2020/044万,主持

  6. 深圳市基础研究自由探索项目,2019/03-2021/0350万,主持


主要获奖/社会兼职/荣誉称号

  1. 中华眼科学会奖(2018

  2. 中华医学会眼科分会青年委员(2016

  3. 福建省首批高层次引进人才(2016


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