廖怿

廖怿 助理教授

学科(方向):眼科学

所在系部:眼科研究所

办公电话:0592-2183761

邮    箱:liaoyilori@xmu.edu.cn

系部网址:http://eye.xmu.edu.cn/


研究领域:

年龄相关性黄斑变性(age-related macular degeneration, AMD)是一类威胁中老年人生活质量的不可逆致盲性眼病。其发病率随年龄不断上升,在80岁以上老年人中超过50%。随着中国人口老龄化的加剧,将造成社会和经济的严重负担。根据AMD的临床表现形式,将其区分为两大类:干性AMD,主要表现为视网膜色素上皮(retinal pigment epithelium, RPE)的退化变性和黄斑区感光细胞的死亡,也称为地图样萎缩(geographic atrophyGA)或萎缩性AMDatrophic AMD);湿性AMD,主要表现为脉络膜新生血管,也称为渗出性AMD(exudative AMD)。目前,湿性AMD已经可以通过抗VEGF疗法得到控制,但是干性AMD依然缺乏有效的治疗手段。本课题组致力于揭示脂褐质沉积与RPE及感光细胞死亡退化、炎症之间的相互联系,为开发治疗干性AMD的新疗法提供依据。

学习经历:

2003~2007 武汉大学生命科学正规赌博十大网站app  生命科学与技术基地班  本科;

2007~2013 新泽西州立罗格斯大学  罗伯特伍德医正规赌博十大网站app      博士。

工作经历:

2014.10~至今 正规赌博十大网站app   助理教授

代表性成果:

  1. Chu, H. P.*, Liao, Y.*, Novak, J. S.*, Hu, Z., Merkin, J. J., Shymkiv, Y., Braeckman, B. P., Dorovkov, M. V., Nguyen, A., Clifford, P. M., Nagele, R. G., Harrison, D. E., Ellis, R. E., & Ryazanov, A. G. (2014). Germline quality control: eEF2K stands guard to eliminate defective oocytes. Dev Cell, 28(5), 561-572. doi:10.1016/j.devcel.2014.01. 027 (Co-first author)

  2. Liao, Y.*, Chu, H. P.*, Hu, Z., Merkin, J. J., Chen, J., Liu, Z., Degenhardt, K., White, E., & Ryazanov, A. G. (2016). Paradoxical roles of elongation factor-2 kinase in stem cell survival. J Biol Chem. doi:10.1074/jbc.M116.724856 (Co-first author)

  3. Zhao, J., Liao, Y., Chen, J., Dong, X., Gao, Z., Zhang, H., Wu, X., Liu, Z., & Wu, Y. (2017). Aberrant Buildup of All-Trans-Retinal Dimer, a Nonpyridinium Bisretinoid Lipofuscin Fluorophore, Contributes to the Degeneration of the Retinal Pigment Epithelium. Invest Ophthalmol Vis Sci, 58(2), 1063-1075. doi:10.1167/iovs.16-20734

主持过的重要课题:

  1. 国家自然科学基金青年项目,81700864RIP1/RIP3介导的程序性坏死在视循环紊乱引起的感光细胞退化中的作用机制研究,2018/01-2020/12,主持

  2. 福建省中青年教师教育科研项目一般项目,全反式视黄醛调控视网膜色素上皮自噬的作用及机制研究,2016/11-2018/11,主持

  3. 福建省自然科学基金面上项目,2016J01412,靶向延长因子-2激酶 (eEF2K)抑制糖尿病视网膜神经节细胞退化的机制研究,2016/04-2019/04,主持

  4. 教育部留学回国人员科研启动基金,DNA损伤应答中延长因子-2激酶与p53的相互调控机制探讨,2015/07-2017/07,主持

所有论文列表:

  1. Wan, X., Liu, H. M., Liao, Y., Su, Y., Geng, J., Yang, M. Y., Chen, X. D., & Shen, P. (2007). Isolation of a novel strain of Aeromonas media producing high levels of DOPA-melanin and assessment of the photoprotective role of the melanin in bioinsecticide applications. J Appl Microbiol, 103(6), 2533-2541. doi:10.1111/j.1365-2672.2007.03502.x

  2. Wan, X., Chai, B., Liao, Y., Su, Y., Ye, T., Shen, P., & Chen, X. (2009). Molecular and biochemical characterization of a distinct tyrosinase involved in melanin production from Aeromonas media. Appl Microbiol Biotechnol, 82(2), 261-269. doi:10.1007/s00253-008-1742-5

  3. Hizli, A. A., Chi, Y., Swanger, J., Carter, J. H., Liao, Y., Welcker, M., Ryazanov, A. G., & Clurman, B. E. (2013). Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase. Mol Cell Biol, 33(3), 596-604. doi:10.1128/MCB.01270-12

  4. Chu, H. P.*, Liao, Y.*, Novak, J. S.*, Hu, Z., Merkin, J. J., Shymkiv, Y., Braeckman, B. P., Dorovkov, M. V., Nguyen, A., Clifford, P. M., Nagele, R. G., Harrison, D. E., Ellis, R. E., & Ryazanov, A. G. (2014). Germline quality control: eEF2K stands guard to eliminate defective oocytes. Dev Cell, 28(5), 561-572. doi:10.1016/j.devcel.2014.01. 027 (Co-first author)

  5. Liao, Y.*, Chu, H. P.*, Hu, Z., Merkin, J. J., Chen, J., Liu, Z., Degenhardt, K., White, E., & Ryazanov, A. G. (2016). Paradoxical roles of elongation factor-2 kinase in stem cell survival. J Biol Chem. doi:10.1074/jbc.M116.724856 (Co-first author)

  6. Ye, M. J., Liu, C. Y., Liao, R. F., Gu, Z. Y., Zhao, B. Y., & Liao, Y. (2016). SMILE and Wavefront-Guided LASIK Out-Compete Other Refractive Surgeries in Ameliorating the Induction of High-Order Aberrations in Anterior Corneal Surface. J Ophthalmol, 2016, 8702162. doi:10.1155/2016/8702162

  7. Zhao, J., Liao, Y., Chen, J., Dong, X., Gao, Z., Zhang, H., Wu, X., Liu, Z., & Wu, Y. (2017). Aberrant Buildup of All-Trans-Retinal Dimer, a Nonpyridinium Bisretinoid Lipofuscin Fluorophore, Contributes to the Degeneration of the Retinal Pigment Epithelium. Invest Ophthalmol Vis Sci, 58(2), 1063-1075. doi:10.1167/iovs.16-20734



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