转发讲座信息:药物代谢朝阳论坛

2016129日,星期五

会前研讨(09:00-16:00庄瑾楼426会议室

朝阳学子演讲比赛 (15:00-17:30)  庄瑾楼515538会议室

20161210日,星期六

8:30-8:45

翔安校区图书馆小报告厅

开幕式

主持人:吴彩胜

大会报告

8:45-10:00

翔安校区图书馆小报告厅

主持人:黄民,林鸽

1:曾

从临床数据到转化药学研究

From   Clinical Data to Translation Medicine

2:丁欣欣

细胞色素P450还原酶系统对药物毒性和精准医学的影响

      Impact of the P450 oxidoreductase   system on drug therapy and precision medicine

3:谢

疾病状态下的肝脏代谢

      Disease Effect on Liver Metabolism

10:05-10:25

茶歇Tea break

大会报告

10:25-12:05

翔安校区图书馆小报告厅

主持人:郑江,李桦

4Edward T   Morgan

      Nitric oxide regulation of cytochrome   P450 expression and function

5:喻爱明

使用小鼠模型快速精准评估药物相互作用

      Fast and precise determination of DDI   in mouse models

6:杨

药物代谢酶特异性探针:从实验室到临床

      Specific probes for drug   metabolizingenzymes: frombench to bed

7:郝海平

代谢调控与靶标发现

      Metabolic regulation guided target   identification

12:00-13:45

海报展示Poster   presentation

午餐会Lunch   break/industry-sponsored talk

13:45-15:15

Session 1

代谢组学与代谢调控

庄瑾楼426会议室

Session   2

转运体研究进展

庄瑾楼521会议室

Chairs:汪晖,郝海平

Lectures   & speakers

1.李飞

代谢组学在研究药物代谢与毒性中的应用

Metabolomics   guides the understanding of drug metabolism and toxicity

2.朱正江

基于LC-MS的代谢组学技术在精准医疗中的应用

LC-MS   based Metabolomics for Precision Medicine

3.刘文

组蛋白去甲基化酶与乳腺癌

Histone   demethylases license estrogen receptor alpha-dependent enhancer RNA and   coding gene activation in breast cancer

4.毕惠嫦

代谢组学在胆汁淤积性肝损伤研究中的应用

Metabolomics-based   study on cholestatic liver injury

Chairs:余露山,洪梅

Lectures & speakers

1.Qingcheng   Mao

胎盘   ABC 转运体在胎儿药物暴露中的作用

Roles of Placental ABC Transporters in Determining   Fetal Exposure to Drugs x

2.蒋惠娣

细胞膜转运体介导的有机阳离子类药物肾脏及胎盘转运

Membrane transporters mediate the renal and   placental transfer of cationic drugs

3.洪梅

人体有机阴离子转运多肽1的寡聚状态研究

Oligomeric assembly of human organic anion   transporting polypeptide 1

4.武卫党

药物转运体与创新药物的研发

The important role of drug transporter in   Innovative drug research and development

15:15-15:30

茶歇Tea   break

15:30-17:00

Session   3

药物代酶研究进展

庄瑾楼426会议室

Session   4

中草药活性成分处置与作用机理

庄瑾楼521会议室

Chairs:相小强,王昕

Lectures & speakers

1.汪维鹏

Rs7911488通过改变miR-1307-3p/TYMS表达影响结肠癌卡培他滨化疗疗效

Rs7911488   modified the efficacy of capecitabine-based therapy in coloncancer through   altering miR-1307-3p and TYMS expression

2.葛广波

羧酸酯酶1-配体相互作用研究进展

Recent   Progress in CE1-ligand interactions

3.邢杰

青蒿素的代谢抑制和代谢诱导

The   auto-inhibition and auto-induction metabolism of artemisinin

4.唐斓

肝肾药物代谢酶基因表达权重网络与转录调控分析

The   Relation of transcriptional factors to the expression and activity of drug   metabolism enzymes in human liver and kidney: Co-expression network analysis   for differential expression

Chairs吴宝剑,吴彩胜

Lectures & speakers

1.刘中秋

附子精准用药的药代动力学基础

Pharmacokinetics   on Precision Medicine of Fuzi(附子)

2.陈卫东

中药活性成分微载体体内处置研究

Research   on the active ingredients of Traditional Chinese medicine by Nano-carriers in   vivo

3.李利

银杏叶提取物的多成分药代动力学研究

Multi-compound   Pharmacokinetic Studies of Ginkgo biloba Leaf Extract

4.刘李

基于肠道黏膜系统诠释口服难吸收中药成分小檗碱和人参皂苷Rb1抗糖尿病的作用

Explanation   of anti-diabetic effect of berberine and ginsenoside Rb1 based on intestinal   mucosa system

17:00-17:25

龙志敏上海爱博才思分析仪器贸易有限公司

SCIEX基于Qtrap技术在DMPK及药物代谢的解决方案

SCIEX   Completed Solution in DMPK and Drug Metabolism with Qtrap Technology

邓欣岛津企业管理(中国)有限公司

单抗药物定量分析新视野

The New Horizon in Quantitative   Analysis of Monoclonal Antibody

18:15-20:15

晚宴Banquet

20161211日,星期日

8:30-10:20

Session   5

药物代谢研究的新方法和新模型

庄瑾楼426会议室

Session   6

新型制剂和生物药物的药代动力学

庄瑾楼521会议室

Chairs:庄笑梅,段小涛

Lectures & speakers

1.朱明社

如何发展适合中国新药研发国情的评估和处理与蛋白转运体有关的不利因素的战略和方法?

Strategy   and approach for assessing and mitigating transporter-associated risk in drug   discovery and development in China

2.赵远胜

Quantitative   prediction of pharmacokinetic drug-drug interactions: a top-down approach

3.张延延

基于生理的药代动力学模型研究药物在中枢神经系统的分布及清除过程

A   Generic Physiologically-Based Pharmacokinetic Modeling Approach to Explore   Drug Distribution and Capacity-Limited Elimination in Central Nervous System

4.吴宝剑

解密Ⅱ相代谢酶-转运体间相互作用

Decoding   the interplay between phase    metabolism and transport

5.王昕

CRISPR系统构建特定CYP3A1/2代谢酶敲除大鼠模型

CRISPR   knockout rat cytochrome P450 3A1/2 model for advancing drug metabolism and   pharmacokinetics research

Chairs:黄建耿,杨艳

Lectures & speakers

1.程泽能

基于复杂消除机制的单克隆抗体药物药动学模型研究

A novel PK model based on drug’s complex   elimination for monoclonal antibodies

2.孙进

基于药物转运体的口服药物传递

Oral drug delivery based on drug transporters

3.朱铉

介孔硅/Fe3O4递药系统在肿瘤靶向给药中的应用

Application of mesoporous silica nanoparticles/Fe3O4   in targeting drug delivery system of antitumor drug

4.黄建耿

嵌段聚合物胶束对肝CYP450酶活性的影响

Effect of block polymeric micelles on the activity   ofhepatic CYP450 isozymes

5.杨艳

靶向给药体系的设计及药代动力学研究

Construction and pharmacokinetics study of   targeting delivery system

10:20-10:35

茶歇Tea   break

10:35-12:05

Session   7

基于模型体系的创新药开发策略

庄瑾楼426会议室

Session   8:药物代谢和代谢组学研究中的新技术与新模型

庄瑾楼521会议室

Chairs:刘东阳,相小强

Lectures & speakers

1.吕闯

Application of preclinical DMDPK data towards the   clinical DDI trial design

2.周田彦

两个抗癌新化合物基于机制的PK/PD模型

Mechanism-based PK/PD models for two anticancer   candidates

3.赵维

Modeling and Simulation as research tools in   pediatric drug development

4.刘东阳

基于模型的药物开发策略在创新降糖药早期临床研究中的应用

The application of model-based drug development   strategy for novel anti-diabetic drugs in early phase clinical trials

Chairs:陶怡,吴彩胜

Lectures & speakers

1.张金兰

基于靶向代谢组学中药作用机制和物质基础的研究

Studying   on Mechanism and Material Basis of Traditional Chinese Medicine Based on   Targeted Metabolomics

2.段小涛

肿瘤代谢研究新技术: 化学探针与代谢流分析

Cancer   Metabolic Reprogramming: New Insights from Chemical Probing and Metabolic   Flux

3.张真庆

海藻寡糖在生物样品中分析方法的探讨和应用

The   evaluation and application of method to analyze oligosaccharides from   alginate in biological samples

4.贺玖明

敞开式质谱分子成像技术及其在药物分析中的应用研究进展

Ambient   Mass Spectrometry Imaging and Its Application in Pharmaceutical Analysis

12:05-13:30

海报展示Poster   presentation

午餐会Lunch   break/industry-sponsored talk

13:30-14:35

Session   9

DMPK与个体化用药和精准医疗、

庄瑾楼426会议室

Session   10

药物代谢介导的毒性机制

庄瑾楼521会议室

Chairs张伟,毕惠嫦

Lectures & speaker

1.张伟

基因组学为指导的个体化治疗

Personalized   medicinal management guided by genomics

2.钟诗龙

冠心病患者阿托伐他汀及其活性代谢物循环暴露的预测价值及全基因组关联性研究

Prognostic   value of plasma atorvastatin and its active metabolitesin patients with   coronary heart disease and genome-wide association study

3.尹继业

非小细胞肺癌铂类化疗药物基因组学研究

The   pharmacogenomics of platinum-based chemotherapy of NSCLC

Chairs:房中则,葛广波

Lectures & speakers

1.刘云岗

重组表达药物代谢酶的细胞系在毒理学研究中的应用

Application   of cell lines genetically engineered for expression of drug-metabolizing   enzymes in toxicological studies

2.郭喻

Fetal   programming effect of xenobiotics on cytochrome P450 expression and its   pharmacokinetics/physiological significance

3.彭缨

苯溴马隆的代谢活化及其肝毒性机理研究

Mechanistic   study of metabolic activation and hepatotoxicity of benzbromarone

14:35-14:45

茶歇Tea   break

14:45-16:15

Session   11

药动学相互作用应用与机制

庄瑾楼426会议室

Session   12

非肝脏代谢与其他特殊DMPK

庄瑾楼521会议室

Chairs:王昕,石荣

Lectures & speakers

1.石荣

小檗碱对二甲双胍药动学影响及机制研究

The effect of berberine on the pharmacokinetics of   metformin in rats

2.孙鹏远

转运体介导的药物在肝脏摄取和排泄药动学机制

Pharmacokinetics Mechanismsof Hepatic Transporter   Mediated Drug Uptake and Excretion

3.相小强

基于生理药动建模技术预测五酯胶囊和他克莫司的药动相互作用

Prediction of the pharmacokinetic interaction   between Wuzhi capsule and tacrolimus using PBPK modeling

4.房中则

葡萄糖醛酸转移酶抑制引起的临床替格瑞洛-阿司匹林相互作用

UDP-glucuronosyltransferases (UGTs) inhibition-mediated   Ticagrelor-Aspirin interaction

Chairs:燕茹,张庆宇

Lectures & speakers

1.张庆宇

肠道P450酶的调控和功能

Regulation   and Function of Intestinal P450 Enzymes

2.庞晓雁

二肽基肽酶介导氰基吡咯烷类DPP4抑制剂的氰基水解代谢研究

Hydrolytic   Metabolismof Cyanopyrrolidine DPP4 Inhibitors Mediated by Dipeptidyl   Peptidases (DPPs)

3.庄笑梅

有机磷化合物的代谢激活和减毒

Bioactivation   and detoxification metabolism of organophosphorus compounds

4.燕茹

腸道菌群β-葡萄糖醛酸苷酶:gus基因分析、功能表征以及抑制劑篩選

Gut   microbial β-glucuronidases: gus gene profiling, functional characterization,   and inhibitor screening

16:15-16:30

茶歇Tea   break

16:30-17:45

庄瑾楼426会议室

青年交流专场

Chairs:钟大放、林鸽、李桦

Lectures & speakers

1.卢琳琳

中药活性成分在肿瘤表皮间质转化中的作用

Traditional Chinese medicines in   epithelial-to-mesenchymal transition

2.王昕

抗癫痫新药氯桂丁胺与药物代谢酶CYP450的相互作用

The interaction between 3,4-dichlorophenyl-propenoyl-   sec.-butylamine (3,4-DCPB), a novel antiepileptic drug, and cytochrome P450   metabolic enzymes

3.颜苗

肾移植受者伏立康唑群体药代动力学研究及个体化用药实践

Population Pharmacokinetic Study of Voriconazolein   Renal Transplant Recipients and PharmacyPractice in Individualized Medication

4.何伟

纳米药物与球蛋白之间相互作用与生物行为

The interplay between nanodrug particles and its   potential biological performance

5.许晨舒

SUMO化翻译后修饰在核受体PXR功能调控中的作用

Regulation of Nuclear Receptor PXR by SUMOylation

17:45-18:00

庄瑾楼426会议室

闭幕式

朝阳学子颁奖

主持人:朱明社、毕惠嫦


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