尹震宇


尹震宇 教授/主任医师/博导

学科专业:肝胆胰外科、肿瘤外科

研究方向:肝胆胰肿瘤基础与临床、器官移植

办公电话0592-2292206

邮    箱yinzy@xmu.edu.cn



学习经历:

1988~1993  南京大学医正规赌博十大网站app临床医学专业 医学学士;

1993~1995  南京大学医正规赌博十大网站app外科学       医学硕士(七年制);

2001~2004  南京大学医正规赌博十大网站app外科学       医学博士;

工作经历:

1995~1998  厦门大学附属中山医院               住院医师;

1999~2004  厦门大学附属中山医院               主治医师;

2005~2006  美国匹兹堡大学starzl器官移植研究所  博士后;

2006~2007  美国克利夫兰临床基金会(CCF)        博士后;

2005~2010  厦门大学附属中山医院肝胆外科       副主任医师;

2007~2014  厦门大学附属中山医院肝胆外科       主任;

2011~至今  厦门大学附属中山医院              主任医师;

2011~至今  厦门大学                          教授;

2011~至今  厦门市消化系统肿瘤转化医学重点实验室 常务主任;

2012~至今  正规赌博十大网站app                   博士研究生导师;

2013~至今  福建省慢性肝病肝癌重点实验室      常务主任;

2016~2017  上海复旦大学附属中山医院         院长助理(挂职)

2014~至今  厦门大学附属中山医院              副院长;

代表性成果:

  1. Xie CR, Wang F, Zhang S, Wang FQ, Zheng S, Li Z, Lv J, Qi HQ, Fang QL, Wang XM, Yin ZY*. Long Noncoding RNA HCAL Facilitates the Growth and Metastasis of Hepatocellular Carcinoma by Acting as a ceRNA of LAPTM4B. Molecular Therapy - Nucleic Acids. 2017 December, Pages 440-451.

  2. Chi XYin Z, Jin JLi HZhou JZhao ZZhang SZhao WXie CLi JFeng MLin HWang XGao J. Arsenite-loaded nanoparticles inhibit the invasion and metastasis of a hepatocellular carcinoma: in vitro and in vivo study. Nanotechnology. 2017; 28(44):445101.

  3. Luo PYin PHua RTan YLi ZQiu GYin ZXie XWang XChen WZhou LWang XLi YChen HGao LLu XWu TWang HNiu JXu G. A large-scale, multi-center serum metabolite biomarkers identification study for the early detection of hepatocellular carcinoma. Hepatology. 2017 Sep 28. doi: 10.1002/hep.29561.

  4. Zhang S, Chen Q, Liu Q, Li Y, Sun X, Hong L, Ji S, Liu C, Geng J, Zhang W, Lu Z, Yin ZY, Zeng Y, Lin KH, Wu Q, Li Q, Nakayama K, Nakayama KI, Deng X, Johnson RL, Zhu L, Gao D, Chen L, Zhou D..Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2. Cancer Cell. 2017;31(5):669-684.

  5. Zhen MCWang FQWu SFZhao YLLiu PGYin ZY*. Identification of mTOR as a primary resistance factor of the IAP antagonist AT406 in hepatocellular carcinoma cells. Oncotarget. 2017; 8(6):9466-9475.

  6. Wang F, Yang H, Deng Z, Su Y, Fang Q, Yin Z*. HOX Antisense lincRNA HOXA-AS2 Promotes Tumorigenesis of Hepatocellular Carcinoma. Cell Physiol Biochem. 2016; 40(1-2):287-296.

  7. Li J, Zhang S, Hu Q, Zhang K, Jin J, Zheng X, Yin Z*, Wang X*. The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocarcinoma cells. Sci Rep  2016; 27; 6:26971.

  8. Xu Y, Zhao W, Xu J, Li J, Hong Z, Yin ZY*, Wang X*. Activated hepatic stellate cells promote liver cancer by induction of myeloid-derived suppressor cells through cyclooxygenase-2. Oncotarget 2016; 23; 7(8):8866-78.

  9. Xie CR, Li Z, Sun HG, Wang FQ, Sun Y, Zhao WX, Zhang S, Zhao WX, Wang XM, Yin ZY*. Mutual regulation between CHD5 and EZH2 in hepatocellular carcinoma. Oncotarget 2015; 6 (38):40940-52.

  10. Fang QL, Yin YR, Xie CR, Zhang S , Zhao WX, Pan C, Wang XM, Yin ZY*. Mechanistic and biological significance of DNA methyltransferase 1 upregulated by growth factors in human hepatocellular carcinoma. Int J Oncol 2015; 46: 782-790.

  11. Wang F, Lu Q, Yan J, Peng Y, Xie C, Su Y, Zhou J, Wang B, Zhao W, Wang X,  Bie P, Yin Z*. Ex vivo hepatectomy and partial liver autotransplantation for hepatoid adenocarcinoma: A case report. Oncol Lett 2015;9(5):2199-2204.

  12. Xie CR, Sun HG, Sun Y, Zhao WX, Zhang S, Wang XM, Yin ZY*. Significance of genetic variants in DLC1 and their association with hepatocellular carcinoma. Mol Med Rep 2015 Sep;12(3):4203-9.

  13. Xie CR, Sun H, Wang FQ, Li Z, Yin YR, Fang QL, Sun Y, Zhao WX, Zhang S, Zhao WX, Wang XM, Yin ZY*. Integrated analysis of gene expression and DNA methylation changes induced by hepatocyte growth factor in human hepatocytes. Mol Med Rep. 2015;12(3):4250-8.

  14. Zhang S, Li J, Liu P, Xu J, Zhao W, Xie C, Yin Z*, Wang X*. Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression. Oncotarget 2015 ; 6(13):11074-86.

  15. Zhao Z, Wang X, Zhang Z, Zhang H, Liu H, Zhu X, Li H, Chi X, Yin Z, Gao J. Real-time monitoring of arsenic trioxide release and delivery by activatable T(1) imaging. ACS Nano 2015;24;9(3):2749-59. 

  16. He F, Li J, Xu J, Zhang S, Xu Y, Zhao W, Yin Z, Wang X. Decreased expression of ARID1A associates with poor prognosis and promotes metastases of hepatocellular carcinoma. J Exp Clin Cancer Res 2015; 34:47.

  17. Zhao W, Xu Y, Xu J, Wu D, Zhao B, Yin Z*, Wang X*. Subsets of myeloid-derived suppressor cells in hepatocellular carcinoma express chemokines and chemokine receptors differentially. Int Immunopharmacol 2015; 26(2):314-21.

  18. Zhang S, Li J, Yin ZY, Liu PG, Zhao WX, Xie CR, Zhao BX, Wang XM. Expression pattern and clinicopathologic significance of NKD1 in human primary hepatocellular carcinoma. APMIS 2015; 123(4):315-20.

  19. Wu H, Wei L, Fan F, Ji S, Zhang S, Geng J, Hong L, Fan X, Chen Q, Tian J, Jiang M, Sun X, Jin C, Yin ZY, Liu Q, Zhang J, Qin F, Lin KH, Yu JS, Deng X, Wang HR, Zhao B, Johnson RL, Chen L, Zhou D. Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis. Nat Commun 2015;19;6:6239.

  20. Wang M, Guo L, Wu Q, Zeng T, Lin Q, Qiao Y, Wang Q, Liu M, Zhang X, Ren L, Zhang S, Pei Y, Yin Z, Ding F, Wang HR. ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance. Nat Commun 2014, 24;5:4901.

  21. Xu YZhao WWu DXu JLin STang KYin Z*Wang X*.Isolation of myeloid-derived suppressor cells subsets from spleens of orthotopic liver cancer-bearing mice byfluorescent-activated and magnetic-activated cell sorting: similarities and differences. Int J Clin Exp Pathol. 2014 15;7(11):7545-53.

  22. Gao SB, Xu B, Ding LH, Zheng QL, Zhang L, Zheng QF, Li SH, Feng ZJ, Wei J, Yin ZY, Hua X, Jin GH. The functional and mechanistic relatedness of EZH2 and menin in hepatocellular carcinoma. J Hepatol 2014; 61(4):832-9.

  23. Zhang CS, Jiang B, Li M, Zhu M, Peng Y, Zhang YL, Wu YQ, Li TY, Liang Y, Lu Z, Lian G, Liu Q, Guo H, Yin Z, Ye Z, Han J, Wu JW, Yin H, Lin SY, Lin SC.The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism. Cell Metab 2014; 20(3):526-40.

  24. Zeng T, Wang Q, Fu J, Lin Q, Bi J,Ding W, Qiao Y, Zhang S, Zhao W, Lin H, Wang M, Deng X Zhou D, Yin Z*, Wang HR*. Impeded nedd4-1-mediated ras degradation underlies ras-driven tumorigenesis. Cell Rep  2014; 7(3):871-82. 

  25. Zhao W, Zhang L, Xu Y, Zhang Z, Ren G, Tang K, Kuang P, Zhao B, Yin Z*,  Wang X*. Hepatic stellate cells promote tumor progression by enhancement of immunosuppressive cells in an orthotopic liver tumor mouse model. Lab Invest 201494:182–191.

  26. Kuang P, Zhao W, Su W, Zhang Z, Zhang L, Liu J, Ren G, Yin Z*, Wang X*. 18β-glycyrrhetinic acid inhibits hepatocellular carcinoma development by reversing hepatic stellate cell-mediated immunosuppression in mice. Int J Cancer 2013;132:1831-41.

  27. Zhang YL, Guo H, Zhang CS, Lin SY, Yin Z, Peng Y, Luo H, Shi Y, Lian G, Zhang C, Li M, Ye Z, Ye J, Han J, Li P, Wu JW, Lin SC. AMP as a Low-Energy Charge Signal Autonomously Initiates Assembly of AXIN-AMPK-LKB1 Complex for AMPK Activation. Cell Metab 2013; 18(4):546-555.

  28. Xu B, Li SH, Zheng R, Gao SB, Ding LH, Yin ZY, Lin X, Feng ZJ, Zhang S, Wang XM, Jin GH. Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription. Proc Natl Acad Sci USA 2013; 110(43):17480-17485.

  29. Zhang S, Wang XM, Yin ZY, Zhao WX, Zhou JY, Zhao BX, Liu PG. Chloride intracellular channel 1 is overexpression in hepatic tumor and correlates with a poor prognosis. APMIS 2013; 121(11):1047-53.

  30. Wu H, Xiao Y, Zhang S, Ji S, Wei L, Fan F, Geng J, Tian J, Sun X, Qin F, Jin C, Lin J, Yin ZY, Zhang T, Luo L, Li Y, Song S, Lin SC, Deng X, Camargo F, Avruch J, Chen L, Zhou D. The Ets Transcription Factor GABP Is a Component of the Hippo Pathway Essential for Growth and Antioxidant Defense. Cell Rep 2013, 30; 3(5):1663-77.  

  31. Zhang L, Mei Y, Fu NY, Guan L, Xie W, Liu HH, Yu CD, Yin Z, Yu VC, You H. TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21. Proc Natl Acad Sci USA 2012; 109(51):20937-42.

  32. Zhao W, Su W, Kuang P, Zhang L, Liu J, Yin Z*, Wang X*. The role of hepatic stellate cells in the regulation of T-cell function and the promotion of hepatocellular carcinoma. Int J Oncol 2012; 41(2):457-464.

  33. Zhao Z, Huang D, Yin Z, Chi X, Wang X, Gao J. Magnetite nanoparticles as smart carriers to manipulate the cytotoxicity of anticancer drugs: magnetic control and pH-responsive release. J Mater Chem 2012; 22:15717-15725.

  34. Zhao W, Ren G, Zhang L, Zhang Z, Liu J, Kuang P, Yin Z*, Wang X*. Efficacy of Mesenchymal Stem Cells Derived from Human Adipose Tissue in inhibition of hepatocellular carcinoma Cells in vitro. Cancer Biother Radio 2012; 27(9):606-613.

  35. Chi XQ, Huang DT, Zhao ZH, Zhou ZJ, Yin ZY, Gao JH. Nanoprobes for in vitro diagnostics of cancer and infectious diseases. Biomaterials 2012; 331):189-206.

  36. Deng ZG,  Zhou JY, Yin ZY*, Peng YY, Wang FQWang XM. Continuous Regional Arterial Infusion Therapy via Drug Delivery Catheter for Severe Acute Pancreatitis with Abdominal Compartment Syndrome. World Journal of Gastroenterology 2011; 17(44): 4911–4916.

  37. Ding F, Yin Z, Wang HR: Ubiquitination in Rho signaling. Curr Top Med Chem 2011; 11(23):2879-2887.

  38. Zhao W, Zhang L, Yin Z, Su W, Ren G, Zhou C, You J, Fan J, Wang X. Activated hepatic stellate cells promote hepatocellular carcinoma development in immunocompetent mice. Int J Cancer 2011; 129(11):2651-61.

  39. Deng Z, Yin Z*, Chen S, Peng Y, Wang F, Wang X. Metastatic splenic fetoprotein-producing adenocarcinoma: Report of a case. Surg Today 2011; 41(6): 854-8.

  40. Yin ZY*, Li N, Wang XM, Ni XD, Jiang F, Li YS and Li JS. Immunological protection of liver graft on simultaneous transplanted small bowel in pigs. Hepatobiliary and Pancreatic Diseases International 2009; 8(4):363-369.

  41. Wang XM, Yin ZY, Yu RX, Peng YY, Liu PG, Wu GY. Preventive effect of regional radiotherapy with phosphorus-32 glass microspheres in hepatocellular carcinoma recurrence after hepatectomy. World J Gastroenterol 2008; 14(4): 518-523

  42. Yin Z, Wu W, Fung JJ, Lu L, Qian S. Co-transplanted hepatic stellate cells enhance vascularization of islet allografts. Microsurgery 200727(4):324-7.

  43. Yin Z, Jiang G, Fung JJ, Lu L, Qian S. ICAM-1expressed on hepatic stellate cells plays an important role in immune regulation. Microsurgery 2007; 27(4):328-32.

主持过的重要课题:

  1. 国家自然科学基金面上项目,81672418,长链非编码RNA-HCAL调控肝细胞肝癌恶性表型的分子机制研究。2017/01-2020/12

  2. 国家自然科学基金专项基金项目科学仪器基础专项,61327001,引入分子影像的肝癌及活体肝移植手术计划与评估设备研究,2014/01-2017/12

  3. 国家自然科学基金面上项目,81372618,肝细胞肝癌中抑癌基因DLC1表达沉默的遗传学与表观遗传学机制,2014/01-2017/12

  4. 973”子课题,2013CB910803,基于蛋白质相互作用网络的p53功能调控机制研究,2013/01-2017/12

  5. 科技部重大传染病防治科技重大专项“十一五”计划(肝癌课题子课题),2012ZX10002-011-005,肝癌微环境对肝癌发生发展和复发转移的调控机制及干预研究,2012/01-2015/12

  6. 国家自然科学基金面上项目,81172286HGFIGF通过DNMT调控肝细胞肝癌恶性表型的甲基化机制。2013/01-2015/12

  7. 973”子课题,2011CB910800-G:糖脂代谢稳态调控的分子机制(肝癌的相关分子生物学机制研究(科技部)2011/01-2015/12

  8. 科技部重大传染病防治”科技重大专项“十一五”计划(肝癌课题子课题),ZX10002-019,肝癌微环境对肝癌发生发展和复发转移的调控机制及干预研究,2008/01-2011/12

  9. 国家自然科学基金面上项目,30872484,骨髓间充质干细胞向肝脏星状细胞定向分化的构建及其在诱导同种异体胰岛细胞移植免疫耐受中的作用,2009/01-2011/12

  10. 福建省卫生系统中青年骨干人才重点项目,原发性肝癌中抑癌基因表达沉默的表观遗传学机制及其干预, 20132015

  11. 厦门市科技局重点项目,肝脏免疫微环境对肝癌发生发展转移及术后复发的作用机制及干预研究,2009-2012年。

  12. 教育部留学归国人员启动基金,骨髓间充质干细胞的免疫抑制作用,2008-2009年。

  13. 福建省自然科学基金,骨髓间充质干细胞诱导胰岛细胞移植物免疫耐受的实验研究,2008-2011年。

已获奖项:

  1. 尹震宇,福建省科技创新领军人才奖,2017年。

  2. 尹震宇,国务院特殊津贴专家,2017

  3. 尹震宇,厦门市科技创新杰出人才奖,2016年。

  4. 尹震宇等,原发性肝癌的创新研究及关键技术的转化应用2015年获福建省科技进步二等奖。

  5. 尹震宇等。《原发性肝癌的基础与临床应用研究》,2012年获厦门市科技进步一等奖。

  6. 尹震宇等。《肝脏星状细胞与同种异体胰岛细胞共同移植诱导胰岛移植物免疫耐受的研究》2009年获厦门市科技进步二等奖。

  7. 王效民,尹震宇等。2008年《局部内放疗预防肝癌切除术后复发的研究》获厦门市科技进步二等奖。

  8. 尹震宇等。2008年《肝肠联合移植动物模型的建立及肝移植诱导同源肠移植物免疫而受的实验研究》获福建省医学科技奖三等奖。


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