陈倩

陈倩 副教授/硕导

学科(方向):眼科学/视网膜血管疾病方向

所在系部:基础医学部

邮    箱:qchen2@xmu.edu.cn

系部网址: http://eye.xmu.edu.cn/

研究领域:

从事眼科糖尿病性视网膜病变的研究,研究的课题主要有经典Wnt信号通路在糖尿病性视网膜中微血管病变发生发展中的作用及致病机制以及miRNAs在糖尿病性视网膜病变中的致病作用,通过研究糖尿病性视网膜的发病机制从而找出新的潜在的治疗途径。

学习经历:

2003~2008  武汉大学医正规赌博十大网站app临床医学专业     学士;

2008~2010  武汉大学医正规赌博十大网站app肿瘤学专业       硕士;

2010~2016  美国俄克拉荷马大学生理学专业   博士。

工作经历:

2016~2017  美国俄克拉荷马大学 博士后;

2017~至今  正规赌博十大网站app,厦门大学眼科研究所  副教授。

代表性成果:

  1. Chen Q, Qiu FF, Zhou KL, Matlock G, Takahashi Y, Yang HF, Moran E, Ma JX. Pathological role of miR-21 in diabetic retinopathy through down-regulation of PPARα. DIABETES. 2017;66:1671–1682.

  2. Chen Q, Ma JX.Canonical Wnt signaling in diabetic retinopathy. VISION RES. 2017;139:47-58.

  3. Chen Q, Takahashi Y, Oka K, Ma JX. Functional differences of VLDLR splice variants in regulating Wnt signaling. Mol Cell Biol 2016;36:2645–2654. PMCID: PMC5038150

  4. Takahashi Y*, Chen Q*, Rajala, Ma JX, MicroRNA-184 modulates canonical Wnt signaling through the regulation of frizzled-7 expression in the retina with ischemia-induced neovascularization. FEBS Lett, 2015 Apr 28; 589(10):1143-9. PMCID: PMC4406844. (* equal contribution)

  5. MurrayAR*,ChenQ*,TakahashiY,ZhouKK,ParkK,MaJX.MiRNA-200b down-regulatesOxidationResistance1(Oxr1)expressionintheretinaoftype 1diabetesmodel.InvestOphthalmolVisSci.,2013.54(3):1689-97.PMCID: PMC3626515. (* equalcontribution, IF:3.427)

主持过的重要课题:

2014.7--2016.6美国心脏病协会博士助研金  资助课题:DifferentialRolesofVLDLR SpliceVariantsin CanonicalWntSignaling Regulation资助经费:5万美元 主持

所有论文链接:

https://www.ncbi.nlm.nih.gov/pubmed/?term=qian+chen+oklahoma+university

  1. Chen Q, Qiu FF, Zhou KL, Matlock G, Takahashi Y, Yang HF, Moran E, Ma JX. Pathological role of miR-21 in diabetic retinopathy through down-regulation of PPARα. DIABETES. 2017;66:1671–1682.

  2. Chen Q, Ma JX.Canonical Wnt signaling in diabetic retinopathy. VISION RES. 2017;139:47-58.

  3. Chen Q, Takahashi Y, Oka K, Ma JX. Functional differences of VLDLR splice variants in regulating Wnt signaling. Mol Cell Biol 2016;36:2645–2654. PMCID: PMC5038150

  4. Takahashi Y*, Chen Q*, Rajala, Ma JX, MicroRNA-184 modulates canonical Wnt signaling through the regulation of frizzled-7 expression in the retina with ischemia-induced neovascularization. FEBS Lett, 2015 Apr 28; 589(10):1143-9. PMCID: PMC4406844. (* equal contribution)

  5. MurrayAR*,ChenQ*,TakahashiY,ZhouKK,ParkK,MaJX.MiRNA-200b down-regulatesOxidationResistance1(Oxr1)expressionintheretinaoftype 1diabetesmodel.InvestOphthalmolVisSci.,2013.54(3):1689-97.PMCID: PMC3626515. (* equalcontribution, IF:3.427)

  6. Qiu FF, Matlock GH, Chen Q, Zhou KL, Du YH, Wang X and Ma JX. Therapeutic effects of PPARα agonist on experimental neovascular age-related macular degeneration. InvestOphthalmolVisSci.,2017 Oct 1;58(12):5065-5075.

  7. Fu H, Vadalia N, Xue ER, Johnson C, Wang L, Yang WY, Sanchez C, Nelson J, Chen Q, Choi ET, Ma JX, Yu J, Wang H, Yang XF. Thrombus leukocytes exhibit more endothelial cell-specific angiogenic markers than peripheral blood leukocytes do in acute coronary syndrome patients, suggesting a possibility of trans-differentiation: a comprehensive database mining study. J Hematol Onco., 2017 Mar 23;10(1):74.

  8. MoranE,DingLX,WangZX,ChengR,ChenQ,MooreR, TakahashiYandMa JX.ProtectiveandAntioxidantEffectsofPPAR-αintheIschemic Retina.Invest Ophthalmol Vis Sci.,2014.2014 May 13;55(7):4568-76. PMCID: PMC4109406.

  9. Hu Y, Chen Y, Ding LX, He XM, Takahashi Y, Gao Y, Shen W, ChengR, ChenQ,QiXP,BoultonM,andMaJX.Pathogenicroleofdiabetes-induced PPAR-αdown-regulationinmicrovasculardysfunction.Proc.Natl.Acad.Sci., 2013.110(38):15401-15406. PMCID: PMC3780907. (IF: 9.423)





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