詹心琪


詹心琪 副教授

学科(方向):生物化学/细胞生物学

所在系部:基础医学部

办公电话:0592-2188421

邮    箱:zxq@xmu.edu.cn


研究领域

有机小分子荧光探针的设计、合成及其在生物成像中的应用。尤其兴趣于具有组织穿透力强的长波长发射特性的荧光探针、以及具有双波长发射特性的能应用于组织细胞中进行精确定量测量的比率型荧光探针的开发研究;光学分子传感与分子识别理论研究。

学习经历:

1984 ~1988 厦门大学化学系 分析化学专业 理学学士

1999 ~2002 厦门大学环境科学正规赌博十大网站app 环境科学与工程专业 硕士学位

2003 ~2010 厦门大学化学化工正规赌博十大网站app 分析化学专业 理学博士学位

工作经历:

1988 ~ 2004  闽南师范大学化学系助理教授、副教授

2004 ~ 至今  正规赌博十大网站app 助理教授、副教授

2013 ~2014   美国伊利诺伊大学香槟分校访问学者(国家留学基金委全额资助)

代表性成果:

1.Lin Qing-Shuang, Huang Yue-Lin, Fan Xiao-Xing, Zheng Xiao-Lan, Chen, Xiao-Lan, Zhan Xin-Qi*, Zheng Hong*. A ratiometric fluorescent probe for hypochlorous acid determination: Excitation and the dual-emission wavelengths at NIR region. Talanta 2017, 170, 496-501.

2. Zhan Xin-Qi*, Su Bing-Yuan, Zheng Hong, Yan Jiang-Hua. Sensing hydrogen peroxide involving intramolecular charge transfer pathway: A boronate-functioned styryl dye as a highly selective and sensitive naked-eye sensor. ANALYTICA CHIMICA ACTA2010, 658 (2), 175-179.

3. Zhan Xin-Qi, Yan, Jiang-Hua, Su, Jin-Hua, Wang, Yi-Chen, He, Jing, Wang, Sheng-Yu, Zheng Hong, Xu Jin-Gou*. Thiospirolactone as a recognition site Rhodamine B-based fluorescent probe for imaging hypochlorous acid generated in human neutrophil cells.SENSORS AND ACTUATORS B-CHEMICAL 2010, 150(2), 774-780.

4. Zhan Xin-Qi, Qian Zhen-Hua, Zheng Hong*, Xu Jin-Gou* Rhodamine thiospirolactone. Highly selective and sensitive reversible sensing of Hg(II). CHEMICAL COMMUNICATIONS 2008, 16, 1859-1861. (被引频次153)

主持过的重要课题:

  1. 国家自然科学基金面上项目:“动脉粥样硬化因子的智能荧光探针及活体分子成像”, 主持人,(81071202, 2011.01 - 2013.12, 已结题)

  2. 福建省自然科学基金:“基于螺环内酰胺及内酯新颖的“闭-开环”机制的光学分子探针研究”主持人,2008-2010, 已结题)。

授权专利:

1. 硫代螺环内酯在细胞内次氯酸检测中的应用。詹心琪,郑洪,许金钩授权(公告)号: CN 101870864 B, 授权(公告)日: 2013. 06. 19

2. 检测次氯酸的荧光探针及其制备方法。郑洪, 詹心琪, 王淑萍授权(公告)号?: CN102382641A,  授权(公告)日: 2012.03.21

3. 基于部花菁的检测次氯酸的荧光探针及其制备方法。郑洪, 王淑萍, 詹心琪授权(公告)号?: CN102391855A, 授权(公告)日: 2012.03.21

所有文章列表:

1. A ratiometric fluorescent probe for hypochlorous acid determination: Excitation and the dual-emission wavelengths at NIR region.  Lin, Qing-Shuang; Huang, Yue-Lin; Fan, Xiao-Xing, Zhan, Xin-Qi*; Zheng Hong*.TALANTA 2017170496-501.

2.Semicarbazide-based naphthalimide as a highly selective and sensitive colorimetric and "turn-on" fluorescent chemodosimeter for Cu2+.  Hu, Xiao-Xiao; Zheng, Xiao-Lan; Fan, Xiao-Xing; Zhan Xin-Qi, Zheng Hong*. SENSORS AND ACTUATORS B-CHEMICAL 2016,227,191-197.  

3. A near infrared colorimetric and fluorometric probe for organophosphorus nerve agent mimics by intramolecular amidation.  Hu, Xiao-Xiao; Su, Yue-Ting; Ma, Yun-Wei; Zhan, Xin-Qi;  Zheng, Hong; Jiang, Yun-Bao. CHEMICAL COMMUNICATIONS    2015, 51(82),   15118-1512                                                                          

4. Advances in modifying fluorescein and rhodamine fluorophores as fluorescent chemosensors  Zheng, Hong ; Zhan, Xin-Qi ; Bian, Qing-Na ; Zhang, Xiao-Juan. CHEMICAL COMMUNICATIONS   2013, 49(5), 429-447.

5.Thiospirolactone as a recognition site Rhodamine B-based fluorescent probe for imaging hypochlorous acid generated in human neutrophil cells.  Zhan, Xin-Qi; Yan, Jiang-Hua; Su, Jin-Hua, et al. SENSORS AND ACTUATORS B-CHEMICAL  2010, 150  2),  774-780.

6. Sensing hydrogen peroxide involving intramolecular charge transfer pathway: A boronate-functioned styryl dye as a highly selective and sensitive naked-eye sensor. Zhan, Xin-Qi; Su, Bing-Yuan; Zheng, Hong; et al.  ANALYTICA CHIMICA ACTA  2010, 658( 2) , 175-179.

7. 3 ',6 '-Bis(diethylamino)-3H-spiro[2-benzothiophene-1,9 '-xanthene]-3-thione.  Su, Bing-Yuan; Zhan, Xin-Qi; Guo, Jian-Nan;et al.  ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE  2008, 64(11) , O2068-U1468.

8. Rhodamine thiospirolactone. Highly selective and sensitive reversible sensing of Hg(II).  Zhan, Xin-Qi; Qian, Zhen-Hua; Zheng, Hong; Xu, Jin-Gou.  CHEMICAL COMMUNICATIONAS,   2008,16,1859-1861.

9. Fluorimetric determination of nitrogen oxides in the air by a novel red-region fluorescent reagent. Zhan, XQ; Li, DH; Zheng, H; Xu, JG. TALANTA  2002,58(5), 855-860.

10. Fluorimetric determination of sulfite by the co-quenching effect of formaldehyde and sulfite on the fluorescence of tetra-substituted amino aluminum phthalocyanine. Zhan, XQ; Li, DH; Zheng, H; Xu, JG.

ANALYTICA CHIMICA ACTA  2001, 448 : 1-2, 71-77.

11. Tetrasubstituted sulphonated aluminum phthalocyanine-cationic surfactant system for fluorimetric determination of ethanol in alcoholic beverage.  Zhan, XQ; Li, DH; Zhu, QZ; Xu, JG. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY  2001,29: 6,  710-712.

12. A sensitive fluorimetric method for the determination of nitrite and nitrate in seawater by a novel red-region fluorescence dye. Zhan, XQ; Li, DH; Zheng, H; Xu, JG. ANALYTICAL LETTERS, 2001,34: 15,  2761-277.

13. Sensitive fluorimetric determination of formaldehyde by the co-quenching effect of formaldehyde and sulfite on the fluorescence of tetra-substituted amino aluminium phthalocyanine. Zhan, XQ; Li, DH; Zhu, QZ; Xu, JG.  ANALYST  2000, 125: 12,  2330-2334.





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