卓仁恭



卓仁恭 助理教授

学科(方向):药理学

所在系部:基础医学部

邮    箱:zhuorg@126.com




研究领域

阿尔茨海默病(AD)病理过程中神经元兴奋性和突触功能发生改变,已知神经调节蛋白1Neuregulin 1NRG1)及其受体ErbB4参与神经元兴奋性和突触可塑性调节并影响AD病理进程;双孔钾通道成员TREK通道受到多种细胞内信号通路的调控,降低或提高TREK通道活性均可调节神经元的兴奋性活动,从而对学习记忆功能产生影响。目前,正采用AD细胞和动物模型,研究NRG1及其受体ErbB4调控TREK通道影响神经元兴奋性和AD病理进程的机制,具体包括:(1)阐明NRG1-ErbB4信号通路对TREK通道的调节作用特点;(2)揭示NRG1-ErbB4信号通路是否通过调节TREK通道影响AD细胞模型和动物模型的神经元兴奋性;(3)揭示NRG1-ErbB4信号通路是否通过调节TREK通道影响AD模型的神经元兴奋性进而影响AD的病理进程,并阐明相关作用机制;


学习经历:

2006.09~2010.06 南方医科大学中药学专业  医学学士;

2010.09~2015.06 南方医科大学药理学专业  医学博士;


工作经历:

2015.09~2017.12 正规赌博十大网站app  博士后;

2018.04~至今   正规赌博十大网站app  助理教授;


代表性成果:

  1. Zhuo RG, Peng P, Liu XY, Yan HT, Xu JP, Zheng JQ, Wei XL*, Ma XY*.Intersubunit Concerted Cooperative and cis-Type Mechanisms Modulate Allosteric Gating in Two-Pore-Domain Potassium Channel TREK-2. Front Cell Neuroscience.2016.00127. eCollection 2016.

  2. Zhuo RG, Peng P, Liu XY, Yan HT, Xu JP, Zheng JQ, Wei XL*, Ma XY*. Allosteric coupling between proximal C-terminus and selectivity filter is facilitated by the movement of transmembrane segment 4 in TREK-2 channel. Scientific Reports,2016; 6:21248.

  3. Zhuo RG, Liu XY, Zhang SZ, Wei XL, Zheng JQ, Xu JP*, Ma XY*. Insights into the stimulatory mechanism of 2-aminoethoxydiphenyl borate on TREK-2 potassium channel. Neuroscience, 2015; 300: 85-93.


主持过的重要课题

  1. 国家自然科学基金青年项目,81601227Neuregulin1-ErbB4调节TREK通道在阿尔茨海默病中的机制研究,2017/01-2019/1217.0万元,在研,主持

  2. 中国博士后科学基金面上项目,2016M590596NRG1-ErbB4调节TREK通道在阿尔茨海默病中的机制研究,2016/07-2018/068.0万元(一等资助),已结题。


所有论文列表:

(1) Zhuo RG, Peng P, Zheng JQ, Zhang YL, Wen L, Wei XL, Ma XY*.The glycine hinge of transmembrane segment 2 modulates the subcellular localization and gating properties in TREK channels. Biochemical and biophysical research communications, 2017 Aug 26;490(3):1125-1131. https://www.ncbi.nlm.nih.gov/pubmed/?term=The+glycine+hinge+of+transmembrane+segment+2+modulates+the+subcellular+localization+and+gating+properties+in+TREK+channels.


(2) Zhuo RG, Peng P, Liu XY, Yan HT, Xu JP, Zheng JQ, Wei XL*, Ma XY*. Intersubunit Concerted Cooperative and cis-Type Mechanisms Modulate Allosteric Gating in Two-Pore-Domain Potassium Channel TREK-2. Front Cell Neuroscience. 2016.00127. eCollection 2016. https://www.ncbi.nlm.nih.gov/pubmed?term=(Intersubunit%20Concerted%20Cooperative%20and%20cis-Type%20Mechanisms%20Modulate%20Allosteric%20Gating%20in%20Two-Pore-Domain%20Potassium%20Channel%20TREK-2.)


(3) Zhuo RG, Peng P, Liu XY, Yan HT, Xu JP, Zheng JQ, Wei XL*, Ma XY*. Allosteric coupling between proximal C-terminus and selectivity filter is facilitated by the movement of transmembrane segment 4 in TREK-2 channel. Scientific Reports,2016; 6:21248.

https://www.ncbi.nlm.nih.gov/pubmed/?term=Allosteric+coupling+between+proximal+C-terminus+and+selectivity+filter+is+facilitated+by+the+movement+of+transmembrane+segment+4+in+TREK-2+channel.


(4) Zhuo RG, Liu XY, Zhang SZ, Wei XL, Zheng JQ, Xu JP*, Ma XY*. Insights into the stimulatory mechanism of 2-aminoethoxydiphenyl borate on TREK-2 potassium channel. Neuroscience, 2015; 300: 85-93.

https://www.ncbi.nlm.nih.gov/pubmed/?term=Insights+into+the+stimulatory+mechanism+of+2-aminoethoxydiphenyl+borate+on+TREK-2+potassium+channel.


(5) Zhuo RG, Peng P, Liu XY, Zhang SZ, Xu JP, Zheng JQ, Wei XL*, Ma XY*. The isoforms generated by alternative translation initiation adopt similar conformation in the selectivity filter in TREK-2. Journal of physiology and biochemistry, 2015; 71(4):601-610. (IF=2.4440)

https://www.ncbi.nlm.nih.gov/pubmed/?term=The+isoforms+generated+by+alternative+translation+initiation+adopt+similar+conformation+in+the+selectivity+filter+in+TREK-2.


(6) Zhuo RG#, Ma XY#, Zhou PL, Liu XY, Zhang K, Wei XL, Yan HT, Xu JP, Zheng JQ*. Mas-related G protein-coupled receptor D is coupled to endogenous calcium-activated chloride channel in Xenopus oocytes. Journal of physiology and biochemistry, 2014; 70(1): 185-191.

https://www.ncbi.nlm.nih.gov/pubmed/?term=Mas-related+G+protein-coupled+receptor+D+is+coupled+to+endogenous+calcium-activated+chloride+channel+in+Xenopus+oocytes.


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