Assistant Professor: Jiaoyue Hu
Postgraduate students: Jufeng Meng, Lijun Ye, Zhongyang Zhao
Among various pathological conditions of diabetes mellitus, ocular complications have been a leading cause of blindness in the world, including diabetic retinopathy, cataract, and various ocular surface disorders. The most recognized diabetic changes in the cornea include impaired corneal sensation, superficial punctate keratitis, and persistent corneal epithelium defects. The uncontrolled impairment of corneal wound healing increases the susceptibility of corneal ulcer, microbial keratitis, and even perforation. Moreover, excess oxidative stress, resulted from enhanced accumulation of ROS and impaired antioxidant capabilities in response to hyperglycemia, has been postulated as an important pathological mechanism. Our group has been committed to the research of diabetic keratopathy pathogenesis, corneal angiogenesis and treatment.
1. Zhenhao Zhang, Yue Huang, Hui Xie, Juxin Pan, Fanfei Liu, Wensheng Chen, Jiaoyue Hu* (Co-Correspanding), Zuguo Liu*. Benzalkonium Chloride Suppresses Rabbit Corneal Endothelium Intercellular Gap Junction Communication, Plos One, 2014 Oct 9;9(10):e109708
2. Wensheng Chen*, Nuo Dong, Caihong Huang, Zhenhao Zhang, Jiaoyue Hu, Hui Xie, Juxin Pan, Zuguo Liu*. Corneal Alternations Induced by Topical Application of Commercial Latantoprost, Travoprost and Bimatoprost in Rabbit, Plos One, 2014 Mar 14;9(3):e89205
3. Wensheng Chen*, Zhenhao Zhang, Jiaoyue Hu, Hui Xie, Juxin Pan, Nuo Dong, Zuguo Liu*. Changes in Rabbit Corneal Innervation Induced by Topical Application of Benzalkonium Chloride, Cornea, 2013;Dec;32(12):1599-606
4. Jiaoyue Hu#, Zhenhao Zhang#, Hui Xie, Lelei Chen, Yueping Zhou, Juxin Pan, Wensheng Chen*, Zuguo Liu*. Serine protease inhibitor A3K protects rabbit corneal endothelium from barrier function disruption induced by TNF-α, Invest Ophthalmol Vis Sci,2013;Aug 9;54(8):5400-7
5. Wensheng Chen#, Jiaoyue Hu# (co-first author), Zhenhao Zhang, Lelei Chen, Hui Xie, Nuo Dong, Yongxiong Chen, Zuguo Liu. Localization and Expression of Zonula Occluens-1 in the Rabbit Corneal Epithelium Following Exposure to Benzalkonium Chloride.Plos One, 2012;7(7):e40893.